It's been over a year since I traded in my Multistrada, so my memory is a bit sketchy. For some reason, the Multi felt great in the showroom, but I never felt really comfortable on it. I'm about 6'2", and it always felt good when I first started out on it, but I think it was the hand/arm position that didn't feel right after a while. It was upright like the Tiger, but didn't that seat always made me feel like I was sitting on top of it. I didn't trade in my '05 Tiger because I was afraid that I wouldn't be able to do 10 hour days on the '07 like I could on the '05, and the Tiger is the bike I travel on. I was wrong, the new one is more comfortable and puts me in a perfect riding position, upright but with a very slight lean forward. Wish I had a better explanation for you, but at 66 I struggle to remember what day it is sometimes (retirement is a wonderful thing).
I think the thing that I never got used to on the Multi was the engine. Even after I changed the gearing, it was still pretty tall, and that bike needs to be above 4k before the engine feels responsive. Much different with the Tiger, it pulls good from 2k on up, with a very even spread of torque. For me, the Tiger just feels more powerful. Also, the Multi never felt really solid to me, like the Tiger does. Even though the Tiger shed a few pounds in the current configuration, it feels very substantial.
I know opinions vary greatly on these matters, the fellow that got my Multi really loves it, and I greatly respect his opinion on bikes, but I never bonded with it for some reason. I honestly can't say anything bad about the Multi (except for the damned kickstand), it's a really good bike, I just never fell in love with it.
You really should try the new Tiger, I think it's a great all around machine. I've only got a little over 1k miles on mine, (the flu bug and bad weather have kept me inside) but I'm already pretty convinced it will be hard to beat for my purposes. Ask playinthestreet, he's coming off a Sprint ST, and seems pretty excited after his first few miles.
Hope this makes sense and helps a little, I'm better at talking than typing.
Dave