I have the front fender taken off of my Bonneville. It hasn't bothered me too much yet and I have gone a couple short trips since (a couple hundred miles). Though if I see a puddle coming up ahead I'll just move my head to the side so I don't get sprayed
However I do live in southern California so the weather isn't too bad.
I'm sure in places with more water and debris on the road it would be a different story.