Go for it!
I had the off-road tune installed (standard can & sprockets) a couple of months ago. As far as I can tell it has had little or no effect on fuel consumption, my last tankfull lasted 204 miles to the light coming on and I still only managed to squeeze 18 and a half litres into it.
Admittedly I was taking it fairly easy over most of it, my light usually comes on at around 180-190 miles both before and after the tune was installed.
The benefits of throttle response, smoother running and better acceleration far outweigh any slight loss of mpg IMHO.
Happy riding!!! :-D