I had a chance to ride the new Aprilia Mille and Tuono this weekend as my dealer had the Aprilia demo truck on site. I traded on 01 RSV Mille for my S3 and I'm a big fan of the Aprilia's. In general, they build a very high quality machine.
New Mille - WOW! Great bike, Olins front/rear are good, radial Brembo's are nice too. The motor is stunning. Handling wise, this is probably the best you can buy. Would I want to ride one all day in congested traffic? No
Tuono - Total *****. first gear is perfect, second gear WAY too tall. By detuning the engine, Aprilia neutered the V60. This bike was really a disapointment.
Riding my S3 after both bikes, I can best describe the S3 as easy to ride. It's almost effortless. It's really enjoyable compared to a v-twin.