I've run them in the past. I didn't notice any real improvement in power or throttle response. I've read they don't foul as quickly if you've messed with the carbs and are running a bit rich.
I have not noticed any significant differences but the bike seems to idle and run smoother with the Iridium's and the long plug life will certainly be a plus.
I can recommend switching any plug from a #8 to a #9 (cooler plug) if you live in a hot climate like I do. I definitely think this helped performance.