Let's put it this way. Your bike won't blow up if you ride it around the block to see how your pipes sound. But you should re-jet as soon as possible. Don't go and put 300 miles on the bike this weekend while waiting for the screws to come in. I doubt if it will do any long term damage, but why risk it?
As far as the mixture screw, no, it's on the bottom of the carbs. The 865cc engines have a "D" shaped screw that does not need to be drilled out. You can either buy a d-tool from NB, or make your own tool from a .22 shell. I used plastic wire crimp connectors remove the screws, then sawed a slot into them so I could use a flathead screwdriver.
Check out these two guides:
Jenks Carb Guide
Dinqua