There are multi-compound tires that are supposedly of harder stuff in the middle, and softer compound on the sides.
I know that dual compound exists already, I've heard of tri-compound that gets continually softer on the edges, but have not actually researched it at all.
Your never going to prevent flattening off your tire unless you strongly change your riding style. my rear tire flattened pretty well, and I have some pretty curvy roads here in VA, too much cruising back and forth to work on the highway and riding out to Winchester on Route 7