Honestly, as I said before, synthetic oil is literally lab built, not mined. There is no logical reason it wouldn't work. Additives may well make a difference but the base oil is JUST better.
People never have problems with synthetic after a rebuild or in new engines. If you use the correct grade, it's just cleaner oil, that's all. It does have detergents added too which just keeps it cleaner. No more sludge trap blocking up! Keeps all oilways clear etc. This is the thing, it'll best to start using synthetic after a rebuild ideally as it'll break up all the rubbish in your system already. People generally get problems from using synthetic because they don't understand what it is or how it works.
It's worth noting as well that UK sold Synthetic is genuine lab built. USA made MIGHT be lab built but it could easily be filtered stuff from a mine. They do filter it more than older oils so it's still the best you can get. European law is stricter on how the branding of oils work. Probably makes no difference to be fair, I imagine the difference is negligible.